Histamine metabolism.

In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis

Primary hyperoxaluria type I (PH1) is an autosomal-recessive inborn error of liver metabolism caused by alanine:glyoxylate aminotransferase (AGT) deficiency. In silico modeling of liver metabolism in PH1 recapitulated accumulation of known biomarkers as well as alteration of histidine and histamine levels, which we confirmed in vitro, in vivo, and in PH1 patients. AGT-deficient mice showed decr...

Diamine oxidase and cadaverine metabolism.

We have recently presented evidence that diamine oxidase is rcsponsiblc for a portion of the metabolism of histamine in several species (1, 2). This evidence is largely based on the alteration of histamine metabolism produced by compounds which are known to inhibit diamine oxidase in vitro. The inhibitors used were isonicotinylhydrazine (3) and aminoguanidine. The latter is reported to be the m...

The relationship between histamine and bone metabolism Doctoral thesis

Sertraline and amitriptyline enhance histamine metabolism in guinea-pig tissues

Background Aside from their typical use to treat depression, many antidepressants are also used to treat anxiety disorders and chronic pain disorders. Moreover, it has been proved that they show anti-inflammatory effects. We believe that a part of this effect of antidepressants can arise as a consequence of histamine elimination from the site of inflammation. In mammals, histamine is mainly met...

Aortic endothelial and smooth muscle histamine metabolism in experimental diabetes.

We studied histamine metabolism, i.e., histidine decarboxylase (HD)-mediated synthesis and histaminase-mediated catabolism, in relation to intracellular histamine content in both aortic endothelial and subjacent smooth muscle cells of control and diabetic rats. Diabetes was induced by a single jugular vein injection of streptozotocin (55 mg/kg in acidified saline, pH 4.5), and animals were held...